Buffalo Sabres Schedule
*All times are Eastern
Regular Season
| 09/21/2015 | 8:00 PM | @ | Minnesota |
| 09/23/2015 | 7:00 PM | Ottawa | |
| 09/25/2015 | 7:30 PM | @ | Toronto |
| 09/26/2015 | 7:00 PM | @ | Ottawa |
| 09/29/2015 | 7:00 PM | Toronto | |
| 10/01/2015 | 8:00 PM | @ | Minnesota |
| 10/02/2015 | 7:00 PM | Columbus | |
| 10/08/2015 | 7:00 PM | Ottawa | |
| 10/10/2015 | 1:00 PM | Tampa Bay | |
| 10/12/2015 | 3:00 PM | Columbus | |
| 10/15/2015 | 7:30 PM | @ | Florida |
| 10/17/2015 | 7:00 PM | @ | Tampa Bay |
| 10/21/2015 | 7:00 PM | Toronto | |
| 10/23/2015 | 7:00 PM | Montreal | |
| 10/24/2015 | 7:00 PM | New Jersey | |
| 10/27/2015 | 7:00 PM | @ | Philadelphia |
| 10/29/2015 | 7:00 PM | @ | Pittsburgh |
| 10/30/2015 | 7:00 PM | Philadelphia | |
| 11/01/2015 | 7:30 PM | @ | Ny Islanders |
| 11/05/2015 | 7:00 PM | Tampa Bay | |
| 11/07/2015 | 1:00 PM | Vancouver | |
| 11/10/2015 | 7:30 PM | @ | Tampa Bay |
| 11/12/2015 | 7:30 PM | @ | Florida |
| 11/14/2015 | 7:00 PM | San Jose | |
| 11/17/2015 | 7:00 PM | Dallas | |
| 11/19/2015 | 8:00 PM | @ | St Louis |
| 11/21/2015 | 8:00 PM | @ | Dallas |
| 11/23/2015 | 7:00 PM | St Louis | |
| 11/25/2015 | 7:00 PM | Nashville | |
| 11/27/2015 | 7:00 PM | Carolina | |
| 11/28/2015 | 8:00 PM | @ | Nashville |
| 12/01/2015 | 7:30 PM | @ | Detroit |
| 12/04/2015 | 7:00 PM | Arizona | |
| 12/06/2015 | 8:00 PM | @ | Edmonton |
| 12/07/2015 | 10:00 PM | @ | Vancouver |
| 12/10/2015 | 9:00 PM | @ | Calgary |
| 12/12/2015 | 7:00 PM | Los Angeles | |
| 12/14/2015 | 7:30 PM | @ | Detroit |
| 12/15/2015 | 7:00 PM | New Jersey | |
| 12/17/2015 | 7:00 PM | Anaheim | |
| 12/19/2015 | 1:00 PM | Chicago | |
| 12/26/2015 | 7:00 PM | @ | Boston |
| 12/28/2015 | 7:00 PM | Washington | |
| 12/30/2015 | 7:00 PM | @ | Washington |
| 12/31/2015 | 6:00 PM | Ny Islanders | |
| 01/02/2016 | 1:00 PM | Detroit | |
| 01/05/2016 | 7:00 PM | Florida | |
| 01/08/2016 | 8:30 PM | @ | Chicago |
| 01/10/2016 | 3:00 PM | @ | Winnipeg |
| 01/12/2016 | 8:00 PM | @ | Minnesota |
| 01/15/2016 | 7:00 PM | Boston | |
| 01/16/2016 | 7:00 PM | Washington | |
| 01/18/2016 | 9:00 PM | @ | Arizona |
| 01/20/2016 | 10:00 PM | @ | Colorado |
| 01/22/2016 | 7:00 PM | Detroit | |
| 01/25/2016 | 7:30 PM | @ | Ny Rangers |
| 01/26/2016 | 7:30 PM | @ | Ottawa |
| 02/03/2016 | 7:00 PM | @ | Montreal |
| 02/04/2016 | 7:00 PM | Boston | |
| 02/06/2016 | 7:00 PM | @ | Boston |
| 02/09/2016 | 7:00 PM | Florida | |
| 02/11/2016 | 7:00 PM | @ | Philadelphia |
| 02/12/2016 | 7:00 PM | Montreal | |
| 02/14/2016 | 12:30 PM | Colorado | |
| 02/16/2016 | 7:30 PM | @ | Ottawa |
| 02/19/2016 | 7:00 PM | @ | Columbus |
| 02/21/2016 | 12:30 PM | Pittsburgh | |
| 02/24/2016 | 10:30 PM | @ | Anaheim |
| 02/26/2016 | 10:30 PM | @ | San Jose |
| 02/27/2016 | 11:00 PM | @ | Los Angeles |
| 03/01/2016 | 7:30 PM | Edmonton | |
| 03/03/2016 | 7:00 PM | Calgary | |
| 03/05/2016 | 1:00 PM | Minnesota | |
| 03/07/2016 | 7:30 PM | @ | Toronto |
| 03/08/2016 | 7:00 PM | Ny Rangers | |
| 03/10/2016 | 7:30 PM | @ | Montreal |
| 03/12/2016 | 1:00 PM | Carolina | |
| 03/16/2016 | 7:00 PM | Montreal | |
| 03/18/2016 | 7:00 PM | Ottawa | |
| 03/19/2016 | 7:00 PM | @ | Toronto |
| 03/22/2016 | 7:00 PM | @ | Carolina |
| 03/26/2016 | 1:00 PM | Winnipeg | |
| 03/28/2016 | 7:30 PM | @ | Detroit |
| 03/29/2016 | 7:00 PM | @ | Pittsburgh |
| 03/31/2016 | 7:00 PM | Toronto | |
| 04/02/2016 | 7:00 PM | @ | Ny Rangers |
| 04/05/2016 | 7:00 PM | @ | New Jersey |
| 04/08/2016 | 7:00 PM | Columbus | |
| 04/09/2016 | 7:30 PM | @ | Ny Islanders |
